The Benefits of NMN on Different Organs of the Human Body – NMNONE® – [NICOTINAMIDE MONONUCLEOTIDE] committed to providing you with the nutritional supplements you need to fully perfect your diet.

November 08, 2021

The Benefits of NMN on Different Organs of the Human Body.

As we grow older, our body becomes weak, which makes us more exposed to diseases. This has made scientists investigate molecules that may have anti-ageing potentials to help us live longer and healthier. Today, nicotinamide mononucleotide (NMN) seems to be the "new fountain of youth" making waves among scientific research. Apart from its reputation as an anti-ageing molecule, NMN supports proper health through its nicotinamide adenine dinucleotide (NAD+) boosting ability.

The Role of NMN

NMN is a naturally occurring molecule present in our cells. It is also the boosting factor of NAD+ in our body. Once NMN is produced in our body, it is easily absorbed into the cells of many regions of the organs including the liver, the heart, skeletal muscle, kidneys, testes, eyes, where it increases nicotinamide adenine dinucleotide (NAD+).

Our cells use NAD+ for a variety of purposes. One crucial function of NAD+ is to produce the energy that our cells need to function. NAD+ also helps to activate proteins that repair damaged DNA and assist in cellular functions. Unfortunately, NAD+ declines with age. Scientists believe that the loss of NAD+ is the primary reason for the health-related problems we face as we age. These studies believe that once we can sustain our body with healthy levels of NAD+ by taking NMN foods and supplements, our body will enjoy youthful health and strength and stability.

Below are some of the targeted benefits of NMN on several organs of the body.

·NMN and the Brain

The human brain is a very vital part of our nervous system. The brain helps us control thought, memory, emotion, vision, temperature, hunger and every process that regulates our body. Recent studies suggest that raising NAD+ levels with NMN helps to improve brain energy metabolism and overall function. A particular experiment by the University of Oklahoma Health Sciences Center proved that NMN supplementation improves blood flow to the brain with a corresponding effect on enhanced brain function (cognition). They came to this conclusion after treating aged mice with NMN for two weeks. The result of the experiment recorded an increase in the mitochondria of brain cells as the mice exhibited better cognitive function and motor skills.

For this reason, a group of scientists from China and Japan believe NMN may be a promising treatment for Alzheimer's disease. The experiment by this group of scientists showed similar results in brain energy metabolism. However, their results recorded a new finding suggesting that NMN reduced cellular stress in neurons, which reduces neuronal cell death.

·NMN and the Kidney

Developing studies suggest that NMN can improve kidney structure and function in people with a diabetes-related kidney disorder. The human kidney helps balance the body's fluids by removing wastes products and excess fluids from the body. The kidneys are also powerful chemical factories that release hormones to regulate blood pressure.

Most patients with diabetes struggle with poor kidney function (a condition called diabetic nephropathy, which is a leading cause of kidney failure). Poor metabolism and improper regulation of NAD+ are usually found in patients with diabetic nephropathy.

Research by Keio University confirms that NMN treatment can improve the kidney's ability to filter substances properly. To prove this, they injected diabetic mice with NMN for two weeks. They discovered a significant improvement in their kidney structure and function. The scientists also recorded a lower death rate as most of the rat models survived the experiment. Lastly, NMN treatment was able to reduce the swelling and enlargement of a particular part of the kidney called the glomeruli. Most Patients with diabetic nephropathy have a swollen glomerulus. It is a substructure of the kidney responsible for filtering blood and the alteration of specialized cells.

·NMN and the Heart

The task of the heart is to pump enough blood to deliver a continuous supply of oxygen and other nutrients to the brain and other vital organs. The heart functions 24 hours a day, and it needs enough energy to carry out this task. Scientists have linked less mitochondria energy with heart failure. They believe that reductions in NAD+ levels result in lower mitochondrial energy.

NMN supplementation has proved to promote the health of the cell's "energy house," the mitochondria, and prevents heart failure. To verify this, scientists from Duke University injected mice with NMN to boost their NAD+ levels. After the treatment, they discovered that the heart of the mice could pump under stressful conditions. This means that the treatment maintained mitochondria health and caused a reduction in the amount of death of heart cells. So far, records from this experiment deduce that NMN can rescue heart function from pressure-induced heart failure.

·NMN and the Skin

The human skin plays a crucial role in their wellbeing. The skin acts as a protective barrier against physical injury and harmful UV radiation. Apart from being a sensory organ, it also prevents the loss of moisture.

There is scientific evidence that harmful UV rays from the sun can cause a reduction in cell NAD+ levels. The reason is that harmful sunlight rays activate certain enzymes in our cells which use NAD+ to repair cell damage caused by these rays. With time, NAD+ levels reduce, leaving skin cells with insufficient NAD+, which can cause poor skin cell growth and dysfunction.

Developing studies suggest that NMN has a protective role in UV stress and will help prevent and treat skin photoaging. Thus, supplementing UV-damaged skin cells with NMN skin restores cell energy production and proliferation and promotes skin cell health during ageing.

·NMN and the Liver

The liver holds the record as the largest solid organ in the body. It primarily removes toxins from the body's blood supply, maintains healthy blood sugar levels, regulates blood clotting, and performs hundreds of other vital functions.

Sometimes the liver can get injured from chronic alcohol use or the buildup of cellular stress caused by oxidation. This injury can cause scarring, known as fibrosis. There is research evidence indicating that NMN works to treat liver disease caused by alcohol consumption. A group of scientists injected mice with NMN and noticed a reduction in the symptoms of markers of tissue scarring. The study's results indicate that increasing NAD+ levels with NMN can prevent liver fibrosis.

·NMN and the Eye

The eye is a delicate organ that allows you to capture beautiful scenes and detect danger within your environment. We see what we see when light enters the pupil and lands on the retina at the back of our eye, forming images. There are two kinds of photoreceptors called rods and cones, which the eyes use to capture accurate images. Rods capture vision at low light and are sensitive to motion, enabling us with "night vision." Under sufficient light, cones help us see the world in detail and give us "colour vision."

Unfortunately, ageing can affect the eye as the blood vessels in the retina become weakened, causing death or malfunction of photoreceptors. In an attempt to test the effectiveness of NMN on this defect, scientists from Washington University School of Medicine, St. Louis, injected visually impaired mice with NMN doses. After 4 weeks, they recorded improved retinal function compared to mice that did not receive the treatment. This shows that replenishing NAD+ with NMN in the eye can prevent photoreceptor degeneration and restore vision.

Conclusion

Studies in animal and human models show that NMN has high effect in NAD+ boosting and anti-aging. The potentials of NMN begins at the cellular level and extends to organs of the body. To scientists, the ultimate goal is to develop NMN treatments that keep organs healthy and allow people to live a long, happy life.