NMN researchers at Washington University School of Medicine have found that the compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice also has clinically relevant effects in people.
The study conducted at the University of Tsukuba: Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study
A study published by a research team from Metro International Biotech and Harvard Medical School A study shows that a pharmaceutical-grade preparation of NMN known as MIB-626 increases blood levels of NAD+ in one week in middle-aged and older adults.
“I believe that aging is a disease. I believe it is treatable. I believe we can treat it within our lifetimes. And in doing so, I believe, everything we know about human health will be fundamentally changed.”
― David A. Sinclair, Lifespan: The Revolutionary Science of Why We Age – and Why We Don’t Have To
Research Evidence of Taking NMN
NMN PREVENTS METABOLIC DISEASES
Metabolic disorders have become a leading cause of life-threatening diseases among adults across the world. High blood pressure, diabetes, and stroke are metabolic diseases that occur when the body cannot release insulin to regulate blood sugar levels.
Research by Washington University School of Medicine in St. Louis NMN shows that NMN has high metabolic effects and can trigger insulin release. During this experiment, 250 mg capsules of NMN per day were administered to over 20 prediabetic women for 10 weeks.
At the end of the study, it was discovered that:
The NMN treatment caused a 25% increase in muscle glucose consumption. This indicates that NMN increases the amount of sugar used by the body to improve metabolism.
NMN improved their muscle cell growth and proliferation. This is a sign that NMN may help to restore joint and muscle function in older adults.
NMN increased the levels of NAD+ present in their blood cells which boosted immunity.
NMN SLOWS AGEING SIGNS
As humans grow old, their NAD+ levels naturally decline. At that stage, their cells are unable to multiply, fight oxidation and function optimally. This leads to age-related diseases like impaired cognition, heart disease, and metabolic disorders.
Current research indicates that NMN delays ageing and may even extend lifespan. This was the result of a study performed by Washington University School of Medicine in St. Louis in 2019.
In the study, old mice with ageing signs were given NMN doses to see if there would be any changes in their behaviour. At the end of the research, it was observed that old mice showed youthful signs like increased physical activity and better sleep. Scientists also discovered that the old mice started developing younger physical appearance like thicker, shinier fur like those of young mice.
NMN IMPROVES BONE FORMATION
Osteoporosis has become a prevalent condition affecting adults with weak, brittle bone structures.
According to a 2019 research done at Nanchang University in China, it was suggested that taking NMN promotes the generation of new bone. The researchers noted that certain enzymes called sirtuins depend on NAD+ to perform their function in the cell. At the end of the study, they concluded that NMN boosts NAD+ levels, which allowed these “sirtuins” to trigger bone-forming abilities in stem cells. This result indicates that high NMN has a long-term benefit on bone formation in the body.
NMN PROTECTS EYE CELLS
Eye decline is a natural sign of ageing. As we grow older, the amount of antioxidants in the eye reduces, causing cell death, stress, and inflammation. This is why older adults suffer from Age-related eye disorders like cataracts. There is evidence that NMN can protect the eye from damage caused by ageing or other factors.
In an experiment conducted by Harvard Medical School, scientists injected a group of mice with 250 mg and 500 mg NMN. The result suggested that NMN reduced cell death and suppressed eye inflammation. They also recorded an increasing level of antioxidants that may combat oxidative stress in the eye.
NMN PROMOTES DNA REPAIR
The ability of our cells to repair DNA declines as we age. This makes DNA damage accumulate in our body and lead to cell malfunction. Scientists have noticed that (NAD+) regulates the chemical process which controls DNA repair.
In research conducted by David Sinclair, a professor of Harvard Medical School and the University of New South Wales, it was believed that restoring NAD+ levels with NMN can protect one against DNA damage and ageing. As part of the experiment, they exposed a set of mice to radiation and selected some old mice to the group. The team treated the mice with an NAD+ booster (NMN) and noticed a good improvement in their DNA. This successful experiment gained attention in America’s space agency who is currently considering NMN as a potential treatment for Astronauts with damage to their DNA.
NMN IMPROVES HEART FUNCTION
Over 20 million people die from heart failure every year. According to a 2017 study, scientists from Duke University discovered that (NMN) had positive effects in mice with heart failure. In the experiment, doses of MSM was administered to genetically modified mice with heart disease.
The results showed that NMN increased the levels of (NAD+), which boosted the energy in heart cells. Our heart needs energy to pump blood continuously and to maintain a healthy heartbeat. Records from this research indicated that NMN promotes the storage of enough energy in the mitochondria (the powerhouse of the cell), which gives the heart power to function correctly.